Description
Product Characteristics:
Aliases: GLCE antibody, KIAA0836 antibody, D-glucuronyl C5-epimerase antibody, EC 5.1.3.17 antibody, Heparan sulfate C5-epimerase antibody, Hsepi antibody, Heparin/heparan sulfate:glucuronic acid C5-epimerase antibody, Heparosan-N-sulfate-glucuronate 5-epimerase antibody
Target Information: Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM, Jun 2008]